The research areas in our laboratory cover fundamental questions in cancer biology from basic research via translational research to precision oncology. The Translational Pancreatic Cancer Research Center with its three main pillars MECHANISM, TECHNOLOGY & TRANSLATION is structured in a way to facilitate forward and reverse translation using technology-driven approaches including advanced model systems such as patient-derived organoids. From a mechanistic perspective, our laboratory is interested in cell fate decisions in carcinogenesis – specifically, in epithelial-to-mesenchymal transition plasticity – and how this relates to tumor cell dissemination and metastasis, intratumoral heterogeneity, and therapy resistance. Ultimately, our aim is to develop novel therapeutic approaches to target dynamic cell fate decisions and heterogeneity in cancer to induce therapeutic vulnerabilities which can be implemented in clinical care.